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TGR-1202 R-enantiomer
CAS No. 1532533-69-9
TGR-1202 R-enantiomer( RP5264 R-enantiomer | TGR1202 R-enantiomer )
Catalog No. M12155 CAS No. 1532533-69-9
TGR-1202 R-enantiomer is is the less active enantiomer of TGR-1202 (Umbralisib), TGR-1202 is a potent, selective, orally available PI3Kδ inhibitor with IC50 of 22 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 311 | Get Quote |
|
| 5MG | 525 | Get Quote |
|
| 10MG | 752 | Get Quote |
|
| 25MG | 1143 | Get Quote |
|
| 50MG | 1521 | Get Quote |
|
| 100MG | 2061 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTGR-1202 R-enantiomer
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NoteResearch use only, not for human use.
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Brief DescriptionTGR-1202 R-enantiomer is is the less active enantiomer of TGR-1202 (Umbralisib), TGR-1202 is a potent, selective, orally available PI3Kδ inhibitor with IC50 of 22 nM.
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DescriptionTGR-1202 R-enantiomer is is the less active enantiomer of TGR-1202 (Umbralisib), TGR-1202 is a potent, selective, orally available PI3Kδ inhibitor with IC50 of 22 nM.
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In VitroUmbralisib R-enantiomer (TGR-1202 R-enantiomer) (Formula A) exhibits a 50% inhibitory concentration (IC50) with respect to the δ type PI3-kinase that is at least 20-fold lower than the inhibitor's IC50 with respect to the rest of the other PI3K isoforms (i.e., a, β, and γ).
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In Vivo——
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SynonymsRP5264 R-enantiomer | TGR1202 R-enantiomer
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1532533-69-9
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Formula Weight571.5492
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Molecular FormulaC31H24F3N5O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1C(C2=CC=CC(F)=C2)=C([C@@H](C)N3N=C(C4=CC=C(OC(C)C)C(F)=C4)C5=C(N)N=CN=C53)OC6=CC=C(F)C=C16
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Chemical Name4H-1-Benzopyran-4-one, 2-[(1R)-1-[4-amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Locatelli SL, et al. Leukemia. 2016 Dec;30(12):2402-2405.
2. Deng C, et al. Blood. 2017 Jan 5;129(1):88-99.
3. Burris HA 3rd, et al. Lancet Oncol. 2018 Feb 20. pii: S1470-2045(18)30082-2.
4. Lampson BL, et al. Expert Opin Investig Drugs. 2017 Nov;26(11):1267-1279.
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